Imatinib → Imatinib Mesylate

Participants

Reaction Conditions

Reaction Steps

Imatinib base (0.5 g) was dissolved in ethyleneglycoldimethylether (4 ml) at 40° C. and methanesulfonic acid was added (63 μl). The solution was cooled to 10° C. and tert-butyl dimethyl ether was added with stirring. Imatinib mesylate Form α was recovered by filtration, washed with tert-butyl dimethyl ether and dried at 80° C. in a stream of nitrogen. Yield 570 mg (95%).

Provenance & Evidence