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HRID562573

反应详情

EQUATION

反应方程式

HRID 562573 的结构方程式

REACTANTS

反应物

3
结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：CN(C)C=CC(=O)c1cccnc1
HCID567033

3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one

C10H12N2O

结构：Cc1ccc([N+](=O)[O-])cc1NC(=N)N.O=[N+]([O-])O
HCID178426711

未命名化合物

PRODUCTS

生成物

1
结构：Cc1ccc([N+](=O)[O-])cc1Nc1nccc(-c2cccnc2)n1
HCID10686149

N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine

C16H13N5O2

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

CONDITIONS

反应条件

温度
0 °C

PROCEDURE

实验过程

248.2 g (0.96 mol) of 2-methyl-5-nitrophenylguanidine nitrate are added to a solution of 170 g (0.96 mol) of 3-dimethylamino-1-(3-pyridyl)-2-propen-1-one in 2.0 liters of isopropanol. After the addition of 42.5 g of sodium hydroxide, the reddish suspension is boiled at reflux for 12 hours. After cooling to 0° C., filtration, washing with 2.0 liters of isopropanol and 3.times.400 ml of methanol and drying, there is obtained N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine, m.p. 195° C.-198° C., Rf=0.68 (methylene chloride:methanol=9.1).

WORKUP

后处理

  1. temperatureat reflux for 12 hours
  2. filtrationfiltration
  3. washwashing with 2.0 liters of isopropanol and 3.times
  4. dry with material400 ml of methanol and drying