HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 562578Generated: November 1, 2026
N-allyl-N-(4-methoxyphenyl)acrylamide → 1-(4-methoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one
https://huagongshe.com/reaction/562578
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-allyl-N-(4-methoxyphenyl)acrylamide | HCID 67006926 | — |
| Catalyst | HCID 178479819 | HCID 178479819 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(4-methoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one | HCID 55267133 | 86% |
Reaction Steps
To a solution of N-allyl-N-(4-methoxyphenyl)acrylamide (150 mg, 0.69 mmol) in degassed methylene chloride (400 mL) was added Grubbs catalyst (58 mg, 0.069 mmol) and the mixture was heated to 40° C. overnight. All volatiles were removed and the resulting material was subjected to flash chromatography (Hexanes:EtOAc 1:1) to yield 1-(4-methoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one (110 mg, 86%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08067415B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-98cec8a0e98243c791ffe65931dc643d |
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| Source note | uspto-grants-2011_11 |
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