反应详情

温度

70 °C

Dasatinib butanolate (form BU-2, 1.00 g, 2.05 mmol) was heated in a mixture of ethanol (22 ml) and water (3 ml) at 75-80° C. to achieve complete dissolution. Water was added (8 ml) at the same temperature. The solution was cooled to 70° C. and maintained at 70° C. for 1 h. Temperature was lowered from 70° C. to 5° C. during 2 h, and maintained between 0-5° C. for 2 h. The product was filtered and washed with EtOH/H2O (1:1, 2×10 ml) and dried under reduced pressure at 40° C./8 h. Yield: 0.61 g.

1. dissolutiondissolution
2. temperaturemaintained at 70° C. for 1 h
3. temperaturemaintained between 0-5° C. for 2 h
4. filtrationThe product was filtered
5. washwashed with EtOH/H2O (1:1, 2×10 ml)
6. customdried under reduced pressure at 40° C./8 h