反应详情

温度

70 °C

Dasatinib (form A3, 3.50 g) was dissolved in a mixture of i-PrOH—H2O 30:8 (in 140 ml) under reflux. The solution was slowly cooled to about 70° C. The product started to crystallized at 65-70° C. Temperature was kept at this value for about 20 min then it was decreased to 50° C. and kept for 15 min. The mixture was slowly cooled to room temperature and stirred at room temperature for 1 h. The product was filtered off, washed with i-PrOH (2×) and dried under reduced pressure at 50° C. for 3 h. Yield: 2.44 g.

1. temperatureunder reflux
2. customto crystallized at 65-70° C
3. customwas decreased to 50° C.
4. waitkept for 15 min
5. temperatureThe mixture was slowly cooled to room temperature
6. filtrationThe product was filtered off
7. washwashed with i-PrOH (2×)
8. customdried under reduced pressure at 50° C. for 3 h