Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,8-Diazabicyclo(5.4.0)undec-7-ene → [4-(2,4-Dioxo(1,3-dihydroquinazolin-3-yl))phenyl]-n-[(5-chloro(2-thienyl))sulfonyl]carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 반응물 | Methyl 2-isocyanatobenzoate | HCID 519494 | — |
| 반응물 | (4-Aminophenyl)-n-[(5-chloro(2-thienyl))sulfonyl]carboxamide | HCID 131724995 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | [4-(2,4-Dioxo(1,3-dihydroquinazolin-3-yl))phenyl]-n-[(5-chloro(2-thienyl))sulfonyl]carboxamide | HCID 20800263 | 34% |
반응 단계
A 44 mg portion (0.14) of (4-aminophenyl)-N-[(5-chloro(2-thienyl))sulfonyl]carboxamide was combined with 25 mg (0.14 mmol) of methyl 2-isocyanatobenzoate in 500 uL of THF followed by the addition of 1 equivalent of TEA (24 μL) and 1 equivalent of DBU. After 18 h, the mixture was purified by RP-HPLC, to give 21 mg (34%) of the desired compound. ES-MS (M+H)+=462 (Cl).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08067428B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-37890575c16741a19bfeda269e53511f |
| 출처 메모 | uspto-grants-2011_11 |