Azepane → 9-[4-(Hexahydro-1H-azepin-yl)butyl]-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine

Participants

Role	Name	HCID	Charge
Reactant	Azepane	HCID 8119	—
Reactant	1-Bromo-4-chlorobutane	HCID 81364	—
Reactant	N2-Butyl-9-[4-(hexahydro-1H-azepin-1-yl)butyl]-8-(methyloxy)-9H-purine-2,6-diamine	HCID 59252652	—
Reactant	HCID 178448285	HCID 178448285	—
Product	9-[4-(Hexahydro-1H-azepin-yl)butyl]-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine	HCID 59252614	—

Reaction Steps

Prepared similarly to Intermediate 36 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-1H-purin-6-amine trifluoroacetate, 1-bromo-4-chlorobutane, and hexahydro-1H-azepine but with three sequential MDAPs using Method B followed by Method A (×2).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08067426B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-1d40e68ecbcd4e5c9d5d72be8d03f8f4
Source note	uspto-grants-2011_11