But-1-ene-1,3-dione → N-(4-(dihexylamino)-3-fluorophenyl)-3-oxobutanamide

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-fluoro-N1,N1-dihexylbenzene-1,4-diamine (2.94 g, 10.0 mmol) in toluene (50 mL) was added acetyl ketene (0.84 g, 10.0 mmol) and the mixture was stirred at 80° C. overnight. The mixture was cooled to rt and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:4) to give the title compound as yellow oil (2.67 g, 70%).

Provenance & Evidence