Isopropanol → 4-(6-(3-((5-(4-methoxyphenyl)-1,3-oxazol-2-yl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine

Participants

Reaction Steps

The title compound was prepared as described in EXAMPLE 142 substituting EXAMPLE 192B for 2-chlorobenzo[d]oxazole, N-methyl-2-pyrrolidinone for 2-propanol and microwave heating in a Biotage Initiator 2 monomode microwave reactor at 210° C. for 2 hours instead of 80° C. for 18 hours. MS (ESI(+)) m/e 643 (M+H)+; 1H-NMR (300 MHz, DMSO-d6) □ 10.40 (s, 1H), 9.60 (s, 1H), 8.76 (br s, 1H), 8.21 (d, 1H), 7.93 (m, 1H), 7.71 (m, 1H), 7.57-7.40 (m, 6H), 7.28 (s, 1H), 7.17 (m, 1H), 6.99 (m, 4H), 6.60 (d, 1H), 3.77 (s, 3H), 3.76 (m, 4H), 3.12 (m, 4H).

Provenance & Evidence