Trifluoroacetic acid → HCID 67005712, compound

Participants

Reaction Steps

The title compound was prepared as a trifluoracetic acid salt described in EXAMPLE 142 substituting EXAMPLE 193B for 2-chlorobenzo[d]oxazole, N-methyl-2-pyrrolidinone for 2-propanol and microwave heating in a Biotage Initiator 2 monomode microwave reactor at 210° C. for 1 hour instead of 80° C. for 18 hours. MS (ESI(+)) m/e 613 (M+H)+; 1H-NMR (300 MHz, DMSO-d6) □ 10.52 (s, 1H), 9.605 (s, 1H), 8.78 (br s, 1H), 8.22 (d, 1H), 7.95 (m, 1H), 7.73 (m, 1H), 7.59-7.40 (m, 9H), 7.27 (m, 1H), 7.18 (d, 1H), 7.00 (d, 1H), 6.59 (d, 1H), 3.76 (m, 4H), 3.11 (m, 4H).

Provenance & Evidence