Phosgene → 3-Cyanobenzyl 3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenylcarbamate

Participants

Reaction Conditions

Reaction Steps

Into a 2 ml microwave vial was added EXAMPLE 3C (50 mg), 3,5-difluorophenyl)methanol (30.7 mg), 1,1′-carbonyldiimidazole (34.5 mg), 4-(dimethylamino)pyridine (2 mg), and acetonitrile (1065 μl). The mixture was heated in a Biotage Initiator 2 monomode microwave reactor at 150° C. for 25 minutes. Into the vial was added another portion of 1,1′-carbonyldiimidazole (34.5 mg) and the mixture was diluted with 1-methyl-2-pyrrolidinone (900 μl) then heated in an oil bath at 70° C. for 5 hours. To the vial was added (3,5-difluorophenyl)methanol (30.7 mg) and the mixture was heated at 70° C. for 18 hours. The mixture was cooled and phosgene (112 μl) in toluene was added and reaction was stirred at room temperature for 1 week. The mixture was filtered and purified using reverse phase HPLC with 0.1% ammonium hydroxide dissolved in the acetonitrile/water as the mobile phase. MS (ESI(+)) m/e 629 (M+H)+; 1H-NMR (500 MHz, methanol-d4) □ 8.62 (bs, 1H), 7.98 (d, 1H), 7.72-7.76 (m, 1H), 7.67-7.72 (m, 3H), 7.56 (td, 3H), 7.52 (d, 2H), 7.45 (t, 1H), 7.32 (d, 1H), 7.30 (dt, 1H), 7.20 (d, 1H), 6.69 (d, 1H), 5.19 (s, 2H), 3.87-3.94 (m, 4H), 3.33 (s, 4H).

Provenance & Evidence