Phenyl isocyanate → HCID 67005746, compound

Participants

Reaction Steps

The title compound was prepared as described in EXAMPLE 297, with the following substitutions: 4-(6-(3-aminophenyl)imidazo[2,1-b]thiazol-5-yl)-N-(3-(2-morpholinoethyl)phenyl)pyrimidin-2-amine for 4-(6-(3-aminophenyl)imidazo[2,1-b]thiazol-5-yl)-N-(3-(3-morpholinopropoxy)phenyl)pyrimidin-2-amine and isocyanatobenzene for 2,6-difluorobenzoyl chloride. (ESI(+)) m/e 617 (M+H)+; (ESI(−)) m/e 615 (M−H)−; 1H-NMR (300 MHz, DMSO-d6) □9.65 (s, 1H), 8.84 (s, 2H), 8.70 (s, 1H), 8.29 (d, 1H), 7.74 (t, 1H), 7.49-7.63 (m, 4H), 7.43-7.48 (m, 2H), 7.39 (t, 1H), 7.16-7.31 (m, 4H), 6.92-7.01 (m, 1H), 6.87 (d, 1H), 6.63 (d, 1H), 3.52-3.60 (m, 4H), 2.66-2.77 (m, 2H), 2.52-2.57 (m, 2H), 2.36-2.44 (m, 4H).

Provenance & Evidence