Phenylacetyl chloride → HCID 67005357, compound

Participants

Reaction Steps

The title compound was prepared as described in EXAMPLE 297, with the following substitutions: 4-(6-(3-aminophenyl)imidazo[2,1-b]thiazol-5-yl)-N-(3-(2-morpholinoethyl)phenyl)pyrimidin-2-amine for 4-(6-(3-aminophenyl)imidazo[2,1-b]thiazol-5-yl)-N-(3-(3-morpholinopropoxy)phenyl)pyrimidin-2-amine and 2-phenylacetyl chloride for 2,6-difluorobenzoyl chloride. (ESI(+)) m/e 616 (M+H)+; (ESI(−)) m/e 614 (M−H)−; 1H-NMR (300 MHz, DMSO-d6) □ 10.29 (s, 1H), 9.62 (s, 1H), 8.80 (d, 1H), 8.26 (d, 1H), 7.88 (t, 1H), 7.68-7.74 (m, 1H), 7.54-7.61 (m, 2H), 7.49 (d, 1H), 7.40 (t, 1H), 7.18-7.36 (m, 6H), 6.86 (d, 1H), 6.59 (d, 1H), 3.65 (s, 2H), 3.53-3.60 (m, 4H), 3.17 (d, 1H), 2.68-2.76 (m, 2H), 2.52-2.56 (m, 1H), 2.38-2.43 (m, 4H).

Provenance & Evidence