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Benzyl Bromide → 8-Benzyloxy-3-methyl-1H-quinolin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-Methyl-quinolin-2,8-diol | HCID 440986 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 8-Benzyloxy-3-methyl-1H-quinolin-2-one | HCID 22499223 | — |
反応手順
Benzyl bromide (1.28 mL) is added to a suspension of potassium carbonate (2.98 g) in a solution of 8-hydroxy-3-methyl-1H-quinolin-2-one (1.26 g) in acetone (36 mL) at room temperature. The reaction mixture is refluxed for 18 hours, filtered, evaporated and purified by flash column chromatography on silica gel, eluting with 2% methanol in dichloromethane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08067437B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-f5713d447c6240caa8caf73623e1a5cd |
| 出典メモ | uspto-grants-2011_11 |