反应详情

A solution of bromine (0.57 g) in acetic acid (2 mL) is added dropwise to a solution of 8-benzyloxy-3-methyl-1H-quinolin-2-one (0.94 g) and sodium acetate (0.96 g) in acetic acid (12 mL) at room temperature. The reaction mixture is stirred at room temperature for 3 hours, evaporated, the residue partitioned between water (5 mL) and ethyl acetate (5 mL), extracting a further 2× with ethyl acetate (5 mL). Combined organic extracts are dried over magnesium sulphate and purified by flash column chromatography on silica gel, eluting with 2% methanol in dichloromethane.

1. customevaporated
2. customthe residue partitioned between water (5 mL) and ethyl acetate (5 mL)
3. extractionextracting a further 2× with ethyl acetate (5 mL)
4. dry with materialCombined organic extracts are dried over magnesium sulphate
5. custompurified by flash column chromatography on silica gel
6. washeluting with 2% methanol in dichloromethane