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Sodium Hydroxide → 2-Methyl-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]naphthalen-2-ylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2-Methyl-2,3-dihydro-1H-inden-2-amine | HCID 22499229 | — |
| 反応物 | (2-methyl-1-oxo-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]naphthalen-2-yl)-acetamide | HCID 54404642 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Acetic acid sulfuric acid | HCID 23350293 | — |
| 生成物 | 2-Methyl-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]naphthalen-2-ylamine | HCID 22499183 | — |
反応手順
A 4:1 mixture of geometrical isomers, containing predominantly 2,2,2-trifluoro-.N.-(2-methyl-1-oxo-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]naphthalen-2-yl)-acetamide, is hydrogenated over Pd/C in acetic acid/H2SO4 and the products are saponified with NaOH according to the procedures described for the preparation of 2-methyl-indan-2-ylamine. The resulting product mixture is recrystallised repeatedly from hexane to give the title compound, a single isomer.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08067437B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-4839d01654ce4db19a56a8ced8098174 |
| 出典メモ | uspto-grants-2011_11 |