HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Benzyl 1H-pyrrolo[2,3-b]pyridine-5-carboxylate | HCID 57595581 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Product | 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid | HCID 21907018 | 99% |
Reaction Steps
Into a round bottom flask was added compound 22 (55.0 mg, 0.000218 mol) and palladium hydroxide, 20 wt. % Pd on carbon, wet (20.0 mg, 0.000142 mol) and Methanol (5.0 mL, 0.12 mol) under an atmosphere of Hydrogen. The reaction mixture was stirred at room temperature overnight. Filtration and concentration gave product 15 (35 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067434B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-a4d78e4337944a3c824efa5de88762ff |
| Source note | uspto-grants-2011_11 |