HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-Methylsulfanyl-[2,2']bipyridinyl-6-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Diethyl cyanophosphonate | HCID 76257 | — |
| Reactant | 4-Methylsulfanyl-[2,2']bipyridinyl 1-oxide | HCID 59201292 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-Methylsulfanyl-[2,2']bipyridinyl-6-carbonitrile | HCID 56963376 | 72% |
Reaction Steps
4-Methylsulfanyl-[2,2′]bipyridinyl 1-oxide (480 mg, 2.20 mmol) was treated under nitrogen with diethyl phosphorocyanidate and triethylamine in dry acetonitrile following a described procedure (I. Antonioni; G. Cristalli; P. Franchetti; M. Grifantini; S. Martelli, Il Farmaco, 1986, 41, 346-354). Crystallization in ethyl acetate afforded 4-methylsulfanyl-[2,2′]bipyridinyl-6-carbonitrile as a white solid (360 mg, 72% yield)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067441B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-fbfb6f82d4c141a4855306a2a2c7e8ca |
| Source note | uspto-grants-2011_11 |