But-1-ene-1,3-dione → N-(3-fluoro-4-(3-oxomorpholino)phenyl)-3-oxobutanamide

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-(4-amino-2-fluorophenyl)morpholin-3-one (2.51 g, 11.9 mmol) and acetyl ketene (2.51 g, 29.9 mmol) in EtOAc (40 mL) was stirred at 80° C. for 24 h. The mixture was cooled to rt and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:4) to give the title compound as a yellow solid (2.15 g, 61%).

Provenance & Evidence