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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 562888Generated: October 25, 2026

Pentamethylbenzene → Methyl 2-(3-cyano-4-hydroxyphenyl)isonicotinate

https://huagongshe.com/reaction/562888

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPentamethylbenzeneHCID 12784—
ReactantMethyl 2-[4-(benzyloxy)-3-cyanophenyl]isonicotinateHCID 66995135—
SolventTrifluoroacetic acidHCID 6422—
ProductMethyl 2-(3-cyano-4-hydroxyphenyl)isonicotinateHCID 136368377—

Reaction Steps

Methyl 2-[4(benzyloxy)-3-cyanophenyl]isonicotinate and pentamethylbenzene were heated under reflux temperature in trifluoroacetic acid to obtain methyl 2-(3-cyano-4-hydroxyphenyl)isonicotinate. F: 255.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08067446B2
Source datasetuspto-grants-2011_11
ORD IDord-b435b5fd0d6c49fc90b0c27c34855dbd
Source noteuspto-grants-2011_11