Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cesium fluoride → Methyl 2-(3-cyano-4-fluorophenyl)isonicotinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cesium fluoride | HCID 25953 | — |
| 반응물 | Methyl 2-chloropyridine-4-carboxylate | HCID 2736842 | — |
| 반응물 | 3-Cyano-4-fluorophenylboronic acid | HCID 2757964 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | Methyl 2-(3-cyano-4-fluorophenyl)isonicotinate | HCID 66995083 | — |
반응 단계
Cesium fluoride and tetrakis(triphenylphosphine)palladium were added to a 1,2-dimethoxyethane solution of (3-cyano-4-fluorophenyl)boronic acid and methyl 2-chloroisonicotinate, and the mixture was heated under reflux under an argon atmosphere to obtain methyl 2-(3-cyano-4-fluorophenyl)isonicotinate. F: 257.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08067446B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-8ce8508b2c914983a1090894b2a362d7 |
| 출처 메모 | uspto-grants-2011_11 |