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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 562899Generated: October 25, 2026

Methyl 2-chloro-3-oxopropanoate → Methyl 2-[4-(benzyloxy)-3-cyanophenyl]-1,3-thiazole-5-carboxylate

https://huagongshe.com/reaction/562899

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 2-chloro-3-oxopropanoateHCID 14355182—
Reactant4-(Benzyloxy)-3-cyanobenzenecarbothioamideHCID 86626137—
Solvent1-ButanolHCID 263—
ProductMethyl 2-[4-(benzyloxy)-3-cyanophenyl]-1,3-thiazole-5-carboxylateHCID 66995091—

Reaction Steps

4-(Benzyloxy)-3-cyanobenzenecarbothioamide and methyl 2-chloro-3-oxopropionate were heated under reflux in 1-butanol in the presence of Molecular Sieves 4A to obtain methyl 2-[4-(benzyloxy)-3-cyanophenyl]-1,3-thiazole-5-carboxylate. AP: 373(Na).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08067446B2
Source datasetuspto-grants-2011_11
ORD IDord-e89f52d294aa4530a0fe9e65a7a5cd2b
Source noteuspto-grants-2011_11