HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 562901Generated: October 25, 2026
5-Bromo-2-iodobenzonitrile → 5-Bromo-2-pyridin-3-ylbenzonitrile
https://huagongshe.com/reaction/562901
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-Bromo-2-iodobenzonitrile | HCID 7020874 | — |
| Reactant | 3-Pyridylboric acid | HCID 18415377 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Sodium Carbonate | HCID 10340 | — |
| Product | 5-Bromo-2-pyridin-3-ylbenzonitrile | HCID 66995231 | — |
Reaction Steps
5-Bromo-2-iodobenzonitrile and 3-pyridylboric acid were dissolved in a mixture solution of aqueous 2 M sodium carbonate solution and toluene, then tetrakis(triphenylphosphine)palladium was added thereto, and the mixture was heated, stirred with heating in an argon atmosphere at 100° C. for 3 days to obtain 5-bromo-2-pyridin-3-ylbenzonitrile. EI: 258, 260.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08067446B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-1c41b8fe666e4937af3a0fd2585c2cc8 |
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| Source note | uspto-grants-2011_11 |
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