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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 563036Generated: October 30, 2026

4-(6,7-Dimethoxy-2-methylsulfanyl-quinolin-4-yloxy)-3-fluorophenylamine → 4-(4-Amino-2-fluoro-phenoxy)-6,7-dimethoxy-quinolin-2-ylamine

https://huagongshe.com/reaction/563036

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(6,7-Dimethoxy-2-methylsulfanyl-quinolin-4-yloxy)-3-fluorophenylamineHCID 57810073—
ReactantHCID 178486847HCID 178486847—
Product4-(4-Amino-2-fluoro-phenoxy)-6,7-dimethoxy-quinolin-2-ylamineHCID 57810356—

Reaction Steps

4-(4-Amino-2-fluoro-phenoxy)-6,7-dimethoxy-quinolin-2-ylamine was synthesized from 2-amino-6,7-dimethoxy-quinolin-4-ol in a similar manner as 4-(6,7-dimethoxy-2-methylsulfanyl-quinolin-4-yloxy)-3-fluoro-phenylamine, and obtained as a white solid (4.0% yield). LCMS: m/z 330 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08067436B2
Source datasetuspto-grants-2011_11
ORD IDord-97af31f551e843a5a74a1358392c99ce
Source noteuspto-grants-2011_11