HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → Methyl 2-acetamido-4,5-dimethoxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Methyl 4,5-dimethoxyanthranilate | HCID 611144 | — |
| Reactant | N-(4-fluorophenyl)-N'-(4-{[2-methyl-6,7-bis(methyloxy)quinazolin-4-yl]oxy}phenyl)cyclopropane-1,1-dicarboxamide | HCID 57810414 | — |
| Solvent | Heptane | HCID 8900 | — |
| Product | Methyl 2-acetamido-4,5-dimethoxybenzoate | HCID 717609 | — |
Reaction Steps
′N-(4-fluorophenyl)-N′-(4-{[2-methyl-6,7-bis(methyloxy)quinazolin-4-yl]oxy}phenyl)cyclopropane-1,1-dicarboxamide. Commercially available 2-amino-4,5-dimethoxy-benzoic acid methyl ester (3 g, 0.014 mol) and acetic anhydride (4.03 mL, 0.0426 mol) were heated in heptane at 100° C. for 3 hours. After removal of heptane in vacuo, the crude product of 2-acetylamino-4,5-dimethoxy-benzoic acid methyl ester was obtained and used without further purification. LC/MS: m/z 254 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067436B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-b5db8bea1efe41ea81cf10ccbf1b3050 |
| Source note | uspto-grants-2011_11 |