化工社化工社 化学情報印刷レポート · 研究参考用
HRID 563084作成日：2026年10月25日
Dimethylformamide → 4-(4-Chlorophenyl)-5-[3-(2-methoxyphenoxy)propyl]-2-(2-undecyl-1-imidazolyl)oxazole
https://huagongshe.com/reaction/563084
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1H-Imidazole, 2-undecyl- | HCID 85582 | — |
| 反応物 | 2-Chloro-4-(4-chlorophenyl)-5-[3-(2-methoxyphenoxy)propyl]oxazole | HCID 10959800 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(4-Chlorophenyl)-5-[3-(2-methoxyphenoxy)propyl]-2-(2-undecyl-1-imidazolyl)oxazole | HCID 18174719 | 13.4% |
反応手順
A mixture of 2-chloro-4-(4-chlorophenyl)-5-[3-(2-methoxyphenoxy)propyl]oxazole (500 mg), 2-undecylimidazole (500 mg), potassium carbonate (1.38 g) and N,N-dimethylformamide (10 ml) was stirred at 120-130° C. for 4 hours. The reaction mixture was poured into water (100 ml) and extracted with ethyl acetate (100 ml×2). The organic layer was dried over anhydrous magnesium sulfate and concentrated. The residue was recrystallized from diethyl ether-hexane to give 4-(4-chlorophenyl)-5-[3-(2-methoxyphenoxy)propyl]-2-(2-undecyl-1-imidazolyl)oxazole as pale yellow prisms (100 mg, 13%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08067453B2 |
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| 出典データセット | uspto-grants-2011_11 |
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| ORD ID | ord-ee70d74b5da04d0895dd936e314edcac |
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| 出典メモ | uspto-grants-2011_11 |
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