HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3,4-Thiadiazol-2-amine → 3-(1H-indazol-5-yl)-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3,4-Thiadiazol-2-amine | HCID 19909 | — |
| Reactant | 3-(1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid | HCID 59252764 | — |
| Product | 3-(1H-indazol-5-yl)-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide | HCID 24936730 | — |
Reaction Steps
The title compound was prepared from 3-(1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid (Example 29(d)) (44 mg, 0.15 mmol) and 2-amino-1,3,4-thiadiazole using General Coupling Method A to give 29 mg (51% yield) of Example 30. MS found: (M+H)+=378.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067447B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-ec9ba265c0d8447a8de3f1035647735b |
| Source note | uspto-grants-2011_11 |