反应详情

To a solution of (1-(4-fluorophenyl)-1H-indazol-5-yl)(phenyl)methanol (1.2 g, 3.77 mmol) from experimental (1f) in 200 mL of CH2Cl2 was added Dess-Martin Periodinane (2.0 g, 4.71 mmol) portionwise. After 12 h, the reaction was quenched with 1M NaOH and extracted with 3×CH2Cl2. The CH2Cl2 extracts were dried over MgSO4, filtered, and concentrated by rotary evaporator to give (1-(4-fluorophenyl)-1H-indazol-5-yl)(phenyl)methanone in 100% yield. MS found: (M+H)+=317.

1. customthe reaction was quenched with 1M NaOH
2. extractionextracted with 3×CH2Cl2
3. dry with materialThe CH2Cl2 extracts were dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated by rotary evaporator