Silane, ((1-methoxy-2-methyl-1-propenyl)oxy)trimethyl- → HCID 59252780, compound

Participants

Reaction Steps

To a solution of 1-(1-(4-fluorophenyl)-1H-indazol-5-yl)cyclohexanol (500 mg, 1.6 mmol) in DCE (20 mL) was added 1-methoxy-2-methyl-1-trimethylsiloxy-propene (935 uL, 4.8 mmol) followed by TiCl4 (1.7 mL of 1.0 M in DCM). Within 10 min, the reaction was complete. The reaction was quenched with MeOH and then extracted from brine containing dilute HCl with EtOAc×4. The organic layers were dried over MgSO4, filtered, concentrated and purified on SiO2 using 25% EtOAc in hexanes to give 635 mg (100%) of methyl 2-(1-(1-(4-fluorophenyl)-1H-indazol-5-yl)cyclohexyl)-2-methylprop-anoate MS found: (M+H)+=395.

Provenance & Evidence