反应详情

(E)-methyl 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-3-phenylacrylate was dissolved in 30 mL EtOH in a Parr bottle and flushed with N2. 10% Pd on carbon was added and the reaction was put on a Parr shaker under 50 psi of H2 for 7 hours. LC-MS after this time indicated that the reaction was complete so the catalyst was filtered off and the solution concentrated in vacuo. The residue was purified using a 40 g MPLC column using a 10 to 25% EtOAc in hexanes gradient to give methyl 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-3-phenylpropanoate (1.1 g, 64%). MS found: (M+H)+=375.

1. customflushed with N2
2. addition10% Pd on carbon was added
3. filtrationwas filtered off
4. concentrationthe solution concentrated in vacuo
5. customThe residue was purified