1,3,4-Thiadiazol-2-amine → 3-(1-(4-Fluorophenyl)-1H-indazol-5-yl)-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide

Participants

Reaction Steps

Example 136 was prepared from 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-3-phenylpropanoic acid (504 mg, 1.4 mmol) and 2-amino-1,3,4-thiadiazole using General Coupling Method A to give 310 mg (50% yield). MS found: (M+H)+=444. Resolution of this compound into its enantiomers could be accomplished using chiral HPLC as described above.

Provenance & Evidence