反应详情

1-(1-(4-Fluorophenyl)-1H-indazol-5-yl)-3-methylbutan-1-ol (650 mg, 2.17 mmol) was dissolved in 50 mL dry DCM and Dess-Martin periodinane (1.0 g, 2.36 mmol) was added. The reaction mixture was stirred for 12 h. The reaction was poured into 1N NaOH and extracted with DCM×3. The organic layers were dried over MgSO4, filtered, and concentrated to give 600 mg (92% yield) of 1-(1-(4-fluorophenyl)-1H-indazol-5-yl)-3-methylbutan-1-one. MS found: (M+H)+=297.

1. extractionextracted with DCM×3
2. dry with materialThe organic layers were dried over MgSO4
3. filtrationfiltered
4. concentrationconcentrated