1,3,4-Thiadiazol-2-amine → HCID 24937870, compound

HRID 563434Notes

Reaction equation

HRID 563434 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([CH:17]([C:23]4[CH:28]=[CH:27][C:26]([C:29]([O:31][CH3:32])=[O:30])=[CH:25][CH:24]=4)[CH:18]([CH3:22])[C:19](O)=[O:20])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[S:33]1[CH:37]=[N:36][N:35]=[C:34]1[NH2:38]>>[S:33]1[CH:37]=[N:36][N:35]=[C:34]1[NH:38][C:19](=[O:20])[CH:18]([CH3:22])[CH:17]([C:23]1[CH:28]=[CH:27][C:26]([C:29]([O:31][CH3:32])=[O:30])=[CH:25][CH:24]=1)[C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[N:8]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)[N:9]=[CH:10]2

Participants

3

Reactant 2

HCID 199091,3,4-Thiadiazol-2-amineHCID 67005200HCID 67005200, compound

Product 1

HCID 24937870HCID 24937870, compoundYield 25%

Procedure

Example 153 was prepared from 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-3-(4-(methoxycarbonyl)phenyl)-2-methylpropanoic acid and 1,3,4-thiadiazol-2-amine using General Coupling Method A to give 35 mg (25% yield, 3 steps). MS found: (M+H)+=516.

Workup

  1. customto give 35 mg (25% yield, 3 steps)

Sources & evidence

ORD record
ord-9049902acac546488454c8a8a09898c9
Source dataset
uspto-grants-2011_11
Patent number
US08067447B2

Reaction notes

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