1,3,4-Thiadiazol-2-amine → HCID 24937871, compound

HRID 563440Notes

Reaction equation

HRID 563440 reaction equation
[C:1]([O:4][CH2:5][C:6]([CH3:33])([CH:10]([C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[N:22]([C:26]1[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=1)[N:21]=[CH:20]2)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:7]([OH:9])=O)(=[O:3])[CH3:2].[S:34]1[CH:38]=[N:37][N:36]=[C:35]1[NH2:39]>>[C:1]([O:4][CH2:5][C:6]([CH:10]([C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[N:22]([C:26]1[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=1)[N:21]=[CH:20]2)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)([CH3:33])[C:7]([NH:39][C:35]1[S:34][CH:38]=[N:37][N:36]=1)=[O:9])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 199091,3,4-Thiadiazol-2-amineHCID 67005223HCID 67005223, compound

Product 1

HCID 24937871HCID 24937871, compoundYield 39%

Procedure

Example 154 was prepared from 2-(acetoxymethyl)-3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-methyl-3-phenylpropanoic acid (75 mg, 0.168 mmol) and 1,3,4-thiadiazol-2-amine using General Coupling Method B to give 35 mg (39% yield). MS found: (M+H)+=530.

Workup

  1. customto give 35 mg (39% yield)

Sources & evidence

ORD record
ord-da03cd1a402245dda5e903135c09b63c
Source dataset
uspto-grants-2011_11
Patent number
US08067447B2

Reaction notes

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