Acetyl chloride → {2'-[(Acetyl-ethyl-amino)-methyl]-6-fluoro-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester

HRID 563482Notes

Reaction equation

HRID 563482 reaction equation
[CH3:1][O:2][C:3](=[O:26])[CH2:4][C:5]1[CH:6]=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH2:22][NH:23][CH2:24][CH3:25])[C:8]([F:11])=[CH:9][CH:10]=1.[C:27](Cl)(=[O:29])[CH3:28]>>[CH3:1][O:2][C:3](=[O:26])[CH2:4][C:5]1[CH:6]=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:19])([F:20])[F:21])=[CH:14][C:13]=2[CH2:22][N:23]([C:27](=[O:29])[CH3:28])[CH2:24][CH3:25])[C:8]([F:11])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 66603778(2'-Ethylaminomethyl-6-fluoro-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester

Product 1

HCID 66604034{2'-[(Acetyl-ethyl-amino)-methyl]-6-fluoro-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 6, using the following starting materials: (2′-ethylaminomethyl-6-fluoro-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester and acetyl chloride.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8448bd05b90b452ab2e4edd62cbb4f67
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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