2,2,2-Trifluoroethylamine hydrochloride → {6-Fluoro-2'-[(2,2,2-trifluoro-ethylamino)-methyl]-4'-trifluoromethyl-biphenyl-3-yl}acetic acid methyl ester

HRID 563483Notes

Reaction equation

HRID 563483 reaction equation
[CH3:1][O:2][C:3](=[O:24])[CH2:4][C:5]1[CH:6]=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH:22]=O)[C:8]([F:11])=[CH:9][CH:10]=1.Cl.[F:26][C:27]([F:31])([F:30])[CH2:28][NH2:29]>>[CH3:1][O:2][C:3](=[O:24])[CH2:4][C:5]1[CH:6]=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:19])([F:21])[F:20])=[CH:14][C:13]=2[CH2:22][NH:29][CH2:28][C:27]([F:31])([F:30])[F:26])[C:8]([F:11])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 97722,2,2-Trifluoroethylamine hydrochlorideHCID 86633169(6-Fluoro-2'-formyl-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester

Product 1

HCID 86633170{6-Fluoro-2'-[(2,2,2-trifluoro-ethylamino)-methyl]-4'-trifluoromethyl-biphenyl-3-yl}acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 4, Step 1, using the following starting materials: (6-fluoro-2′-formyl-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester and 2,2,2-trifluoroethylamine hydrochloride.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-9696ffa8e8804bf99d9225282f22d4fa
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

Loading…