反应详情

温度

60 °C

[2′-(3-Cyano-1-ethyl-2-phenyl-isoureidomethyl)-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl]-acetic acid ethyl ester (0.10 g, 0.17 mmol) and benzylamine (0.04 mL, 0.34 mmol) were combined in EtOH (1 mL) and heated to 60° C. The reaction was monitored by analytical LCMS, and additional benzylamine (0.04 mL, 0.34 mmol) was added to push the reaction to completion. Further benzylamine (0.10 mL, 0.92 mmol) was added, and the reaction was heated for a total of 48 hours. The mixture was partitioned between EtOAc and H2O, and the aqueous layer was extracted with EtOAc. The combined organic layers were concentrated and purified by silica gel chromatography (0-50% EtOAc in hexanes) to give the title compound.

1. additionwas added
2. customthe reaction to completion
3. temperaturethe reaction was heated for a total of 48 hours
4. customThe mixture was partitioned between EtOAc and H2O
5. extractionthe aqueous layer was extracted with EtOAc
6. concentrationThe combined organic layers were concentrated
7. custompurified by silica gel chromatography (0-50% EtOAc in hexanes)