HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 563551Generated: October 31, 2026
(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester → (3-Hydroxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester
https://huagongshe.com/reaction/563551
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester | HCID 58149337 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (3-Hydroxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester | HCID 59644745 | — |
Reaction Steps
(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester (4.8 mmol) in EtOH was treated with 10% palladium on carbon (10% by weight), and stirred under a balloon of H2 at 60° C. overnight. The mixture was filtered to remove the palladium, and then concentrated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08067445B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-2475c029a7d74009a6c469174bb1c4f8 |
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| Source note | uspto-grants-2011_11 |
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