HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 2-(3-Benzyloxy-5-trifluoromethyl-phenyl)-propionyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-(3-Benzyloxy-5-trifluoromethyl-phenyl)propionic acid | HCID 57458799 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(3-Benzyloxy-5-trifluoromethyl-phenyl)-propionyl chloride | HCID 57458800 | — |
Reaction Steps
To a solution of 2-(3-benzyloxy-5-trifluoromethyl-phenyl)-propionic acid (1.4 g, 4.0 mmol) in CH2Cl2 was added oxalyl chloride (0.76 mL, 8.0 mmol), followed by 3 drops of DMF. After stirring for 15 minutes at room temperature, the mixture was concentrated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067445B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-bf8fb041f48b47b486ebfebdaa6dd46c |
| Source note | uspto-grants-2011_11 |