Benzenepropanoyl chloride → (4'-(6-Ethoxy-pyridin-3-yl)-2'-{[ethyl-(3-phenyl-propionyl)-amino]-methyl}-6-methoxy-biphenyl-3-yl)-acetic acid ethyl ester

HRID 563570Notes

Reaction equation

Cl.[CH2:2]([O:4][C:5](=[O:34])[CH2:6][C:7]1[CH:8]=[C:9]([C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:22]=[N:23][C:24]([O:27][CH2:28][CH3:29])=[CH:25][CH:26]=3)=[CH:17][C:16]=2[CH2:30][NH:31][CH2:32][CH3:33])[C:10]([O:13][CH3:14])=[CH:11][CH:12]=1)[CH3:3].[C:35](Cl)(=[O:44])[CH2:36][CH2:37][C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1>>[CH2:2]([O:4][C:5](=[O:34])[CH2:6][C:7]1[CH:8]=[C:9]([C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:22]=[N:23][C:24]([O:27][CH2:28][CH3:29])=[CH:25][CH:26]=3)=[CH:17][C:16]=2[CH2:30][N:31]([CH2:32][CH3:33])[C:35](=[O:44])[CH2:36][CH2:37][C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[C:10]([O:13][CH3:14])=[CH:11][CH:12]=1)[CH3:3]

Participants

Reactant 2

HCID 64801Benzenepropanoyl chloride

HCID 66958971[4'-(6-Ethoxy-pyridin-3-yl)-2'-ethylaminomethyl-6-methoxy-biphenyl-3-yl]-acetic acid ethyl ester hydrochloride

Product 1

HCID 58149304(4'-(6-Ethoxy-pyridin-3-yl)-2'-{[ethyl-(3-phenyl-propionyl)-amino]-methyl}-6-methoxy-biphenyl-3-yl)-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 6, using the following starting materials: [4′-(6-ethoxy-pyridin-3-yl)-2′-ethylaminomethyl-6-methoxy-biphenyl-3-yl]-acetic acid ethyl ester, hydrochloride and hydrocinnamoyl chloride.

Workup

customPrepared

Sources & evidence

ORD record: ord-3dd4ce5b8fbf4f348f3c069465652ed3
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08067445B2

Reaction notes

Loading…