Phosgene → 3,5-Difluorobenzyl Chloroformate

HRID 563584Notes

Reaction equation

HRID 563584 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:10])[CH:9]=1)[CH2:5][OH:6].[C:11](Cl)([Cl:13])=[O:12]>>[Cl:13][C:11]([O:6][CH2:5][C:4]1[CH:3]=[C:2]([F:1])[CH:9]=[C:8]([F:10])[CH:7]=1)=[O:12]

Participants

3

Reactant 2

HCID 6371PhosgeneHCID 5227213,5-Difluorobenzyl alcohol

Product 1

HCID 574588023,5-Difluorobenzyl Chloroformate

Procedure

Prepared according to the procedure described in Example 56, Step 1, using the following starting materials: 3,5-difluorobenzyl alcohol and phosgene (20% in toluene).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-74b88d963f664b368c6851acb1c5bb75
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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