HCID 58149300, compound → (5-Chloro-4'-fluoro-2'-formyl-biphenyl-3-yl)-acetic acid ethyl ester

HRID 563680Notes

Reaction equation

HRID 563680 reaction equation
[CH2:1]([O:3][C:4](=[O:14])[CH2:5][C:6]1[CH:11]=[C:10]([Cl:12])[CH:9]=[C:8](Br)[CH:7]=1)[CH3:2].[F:15][C:16]1[CH:17]=[CH:18][C:19](B2OC(C)(C)C(C)(C)O2)=[C:20]([CH:23]=1)[CH:21]=[O:22]>>[CH2:1]([O:3][C:4](=[O:14])[CH2:5][C:6]1[CH:7]=[C:8]([C:19]2[CH:18]=[CH:17][C:16]([F:15])=[CH:23][C:20]=2[CH:21]=[O:22])[CH:9]=[C:10]([Cl:12])[CH:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 58149300HCID 58149300, compoundHCID 594202795-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde

Product 1

HCID 58149191(5-Chloro-4'-fluoro-2'-formyl-biphenyl-3-yl)-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: (3-bromo-5-chloro-phenyl)-acetic acid ethyl ester and 5-fluoro-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzaldehyde.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-57e69babbb684d94a5716670ad4e4425
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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