Benzyl isocyanate → [2'-(3-Benzyl-1-ethyl-ureidomethyl)-4'-fluoro-6-methoxy-biphenyl-3-yl]-acetic acid ethyl ester

HRID 563693Notes

Reaction equation

HRID 563693 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[CH2:21][NH:22][CH2:23][CH3:24])[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:2].[CH2:26]([N:33]=[C:34]=[O:35])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[CH2:1]([O:3][C:4](=[O:25])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[CH2:21][N:22]([CH2:23][CH3:24])[C:34]([NH:33][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[O:35])[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 76639Benzyl isocyanateHCID 58149135(2'-Ethylaminomethyl-4'-fluoro-6-methoxy-biphenyl-3-yl)-acetic acid ethyl ester

Product 1

HCID 58149088[2'-(3-Benzyl-1-ethyl-ureidomethyl)-4'-fluoro-6-methoxy-biphenyl-3-yl]-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 95, Step 1, using the following starting materials: (2′-ethylaminomethyl-4′-fluoro-6-methoxy-biphenyl-3-yl)-acetic acid ethyl ester and benzyl isocyanate.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-97a75b2050f8491f921271c70acb6361
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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