HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-fluoropyrimidine → [2'-[(tert-Butoxycarbonyl-ethyl-amino)-methyl]-4'-(5-fluoro-pyrimidin-2-yl)-6-methoxy-biphenyl-3-yl]-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-fluoropyrimidine | HCID 583466 | — |
| Reactant | [2'-[(Tert-butoxycarbonyl-ethyl-amino)-methyl]-6-methoxy-4'-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-3-yl]-acetic acid ethyl ester | HCID 58149092 | — |
| Product | [2'-[(tert-Butoxycarbonyl-ethyl-amino)-methyl]-4'-(5-fluoro-pyrimidin-2-yl)-6-methoxy-biphenyl-3-yl]-acetic acid ethyl ester | HCID 58149243 | — |
Reaction Steps
Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: [2′-[(tert-butoxycarbonyl-ethyl-amino)-methyl]-6-methoxy-4′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-3-yl]-acetic acid ethyl ester and 2-chloro-5-fluoropyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067445B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-7e9dc11d68524c98915fae86c489219c |
| Source note | uspto-grants-2011_11 |