Acetaldehyde → (2'-{[Ethyl-(2-morpholin-4-yl-ethyl)-amino]-methyl}-6'-methoxy-biphenyl-3-yl)-acetic acid methyl ester

HRID 563731Notes

Reaction equation

HRID 563731 reaction equation
[CH3:1][O:2][C:3](=[O:29])[CH2:4][C:5]1[CH:6]=[C:7]([C:11]2[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=2[CH2:19][NH:20][CH2:21][CH2:22][N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[CH:8]=[CH:9][CH:10]=1.[CH:30](=O)[CH3:31]>>[CH3:1][O:2][C:3](=[O:29])[CH2:4][C:5]1[CH:6]=[C:7]([C:11]2[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=2[CH2:19][N:20]([CH2:30][CH3:31])[CH2:21][CH2:22][N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[CH:8]=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 177AcetaldehydeHCID 58148817(6'-Methoxy-2'-[(2-morpholin-4-yl-ethylamino)-methyl]-biphenyl-3-yl}-acetic acid methyl ester

Product 1

HCID 58148792(2'-{[Ethyl-(2-morpholin-4-yl-ethyl)-amino]-methyl}-6'-methoxy-biphenyl-3-yl)-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 33, Step 4, using the following starting materials: {6′-methoxy-2′-[(2-morpholin-4-yl-ethylamino)-methyl]-biphenyl-3-yl}-acetic acid methyl ester and acetaldehyde.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8d9ae7d9ddaf4e4ebbe160cc5e86bc07
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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