(4-Chlorophenyl)methyl chloroformate → (2'-{[(4-Chloro-benzyloxycarbonyl)-ethyl-amino]-methyl}-6,5'-dimethoxy-biphenyl-3-yl)-acetic acid methyl ester

HRID 563747Notes

Reaction equation

HRID 563747 reaction equation
[CH3:1][O:2][C:3](=[O:25])[CH2:4][C:5]1[CH:6]=[C:7]([C:13]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=2[CH2:21][NH:22][CH2:23][CH3:24])[C:8]([O:11][CH3:12])=[CH:9][CH:10]=1.Cl[C:27]([O:29][CH2:30][C:31]1[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=1)=[O:28]>>[CH3:1][O:2][C:3](=[O:25])[CH2:4][C:5]1[CH:6]=[C:7]([C:13]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=2[CH2:21][N:22]([C:27]([O:29][CH2:30][C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=2)=[O:28])[CH2:23][CH3:24])[C:8]([O:11][CH3:12])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 13292914(4-Chlorophenyl)methyl chloroformateHCID 58148841(2'-Ethylaminomethyl-6,5'-dimethoxy-biphenyl-3-yl)-acetic acid methyl ester

Product 1

HCID 58148977(2'-{[(4-Chloro-benzyloxycarbonyl)-ethyl-amino]-methyl}-6,5'-dimethoxy-biphenyl-3-yl)-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 6, using the following starting materials: (2′-ethylaminomethyl-6,5′-dimethoxy-biphenyl-3-yl)-acetic acid methyl ester and 4-chlorobenzyl chloroformate.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-169f7ee00501438ab1af06ef01e421be
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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