Benzyl isocyanate → [2'-(3-Benzyl-1-ethyl-ureidomethyl)-5-chloro-5'-methoxy-biphenyl-3-yl]-acetic acid methyl ester

HRID 563753Notes

Reaction equation

HRID 563753 reaction equation
[CH3:1][O:2][C:3](=[O:24])[CH2:4][C:5]1[CH:6]=[C:7]([C:12]2[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:13]=2[CH2:20][NH:21][CH2:22][CH3:23])[CH:8]=[C:9]([Cl:11])[CH:10]=1.[CH2:25]([N:32]=[C:33]=[O:34])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[CH3:1][O:2][C:3](=[O:24])[CH2:4][C:5]1[CH:6]=[C:7]([C:12]2[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:13]=2[CH2:20][N:21]([CH2:22][CH3:23])[C:33]([NH:32][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[O:34])[CH:8]=[C:9]([Cl:11])[CH:10]=1

Participants

3

Reactant 2

HCID 76639Benzyl isocyanateHCID 58148889HCID 58148889, compound

Product 1

HCID 58149026[2'-(3-Benzyl-1-ethyl-ureidomethyl)-5-chloro-5'-methoxy-biphenyl-3-yl]-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 95, Step 1, using the following starting materials: (5-chloro-2′-ethylaminomethyl-5′-methoxy-biphenyl-3-yl)-acetic acid methyl ester and benzyl isocyanate.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-322428ba2f3643b39c2dffbdd1a905ff
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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