p-Chlorophenoxyacetyl chloride → [5-Chloro-2'-({[2-(4-chloro-phenoxy)-acetyl]-ethyl-amino}-methyl)-5'-methoxy-biphenyl-3-yl]-acetic acid methyl ester

HRID 563754Notes

Reaction equation

HRID 563754 reaction equation
[CH3:1][O:2][C:3](=[O:24])[CH2:4][C:5]1[CH:6]=[C:7]([C:12]2[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:13]=2[CH2:20][NH:21][CH2:22][CH3:23])[CH:8]=[C:9]([Cl:11])[CH:10]=1.[Cl:25][C:26]1[CH:36]=[CH:35][C:29]([O:30][CH2:31][C:32](Cl)=[O:33])=[CH:28][CH:27]=1>>[CH3:1][O:2][C:3](=[O:24])[CH2:4][C:5]1[CH:6]=[C:7]([C:12]2[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:13]=2[CH2:20][N:21]([C:32](=[O:33])[CH2:31][O:30][C:29]2[CH:35]=[CH:36][C:26]([Cl:25])=[CH:27][CH:28]=2)[CH2:22][CH3:23])[CH:8]=[C:9]([Cl:11])[CH:10]=1

Participants

3

Reactant 2

HCID 77771p-Chlorophenoxyacetyl chlorideHCID 58148889HCID 58148889, compound

Product 1

HCID 58149284[5-Chloro-2'-({[2-(4-chloro-phenoxy)-acetyl]-ethyl-amino}-methyl)-5'-methoxy-biphenyl-3-yl]-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 6, using the following starting materials: (5-chloro-2′-ethylaminomethyl-5′-methoxy-biphenyl-3-yl)-acetic acid methyl ester and 4-chlorophenoxyacetyl chloride.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-acc3458e418a42c1a961a676fec052e6
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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