p-Chlorophenoxyacetyl chloride → [2'-({[2-(4-Chloro-phenoxy)-acetyl]-ethyl-amino}-methyl)-6-methoxy-4'-quinolin-6-yl-biphenyl-3-yl]-acetic acid ethyl ester

HRID 563763Notes

Reaction equation

HRID 563763 reaction equation
[CH2:1]([O:3][C:4](=[O:34])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[C:22]4[C:27](=[CH:28][CH:29]=3)[N:26]=[CH:25][CH:24]=[CH:23]4)=[CH:16][C:15]=2[CH2:30][NH:31][CH2:32][CH3:33])[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:2].[Cl:35][C:36]1[CH:46]=[CH:45][C:39]([O:40][CH2:41][C:42](Cl)=[O:43])=[CH:38][CH:37]=1>>[CH2:1]([O:3][C:4](=[O:34])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[C:22]4[C:27](=[CH:28][CH:29]=3)[N:26]=[CH:25][CH:24]=[CH:23]4)=[CH:16][C:15]=2[CH2:30][N:31]([C:42](=[O:43])[CH2:41][O:40][C:39]2[CH:45]=[CH:46][C:36]([Cl:35])=[CH:37][CH:38]=2)[CH2:32][CH3:33])[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 77771p-Chlorophenoxyacetyl chlorideHCID 58149185(2'-Ethylaminomethyl-6-methoxy-4'-quinolin-6-yl-biphenyl-3-yl)-acetic acid ethyl ester

Product 1

HCID 58148790[2'-({[2-(4-Chloro-phenoxy)-acetyl]-ethyl-amino}-methyl)-6-methoxy-4'-quinolin-6-yl-biphenyl-3-yl]-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 6, using the following starting materials: (2′-ethylaminomethyl-6-methoxy-4′-quinolin-6-yl-biphenyl-3-yl)-acetic acid ethyl ester and 4-chlorophenoxyacetyl chloride.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0e179e805faf4604b756123e970273f4
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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