Benzyl isocyanate → [2'-(3-Benzyl-1-ethyl-ureidomethyl)-6-methoxy-4'-(1-methyl-1H-pyrazol-4-yl)-biphenyl-3-yl]-acetic acid ethyl ester

HRID 563767Notes

Reaction equation

HRID 563767 reaction equation
[CH2:1]([O:3][C:4](=[O:30])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[N:22][N:23]([CH3:25])[CH:24]=3)=[CH:16][C:15]=2[CH2:26][NH:27][CH2:28][CH3:29])[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:2].[CH2:31]([N:38]=[C:39]=[O:40])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[CH2:1]([O:3][C:4](=[O:30])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[N:22][N:23]([CH3:25])[CH:24]=3)=[CH:16][C:15]=2[CH2:26][N:27]([CH2:28][CH3:29])[C:39]([NH:38][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[O:40])[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 76639Benzyl isocyanateHCID 58148813[2'-Ethylaminomethyl-6-methoxy-4'-(1-methyl-1H-pyrazol-4-yl)-biphenyl-3-yl]-acetic acid ethyl ester

Product 1

HCID 58149297[2'-(3-Benzyl-1-ethyl-ureidomethyl)-6-methoxy-4'-(1-methyl-1H-pyrazol-4-yl)-biphenyl-3-yl]-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 95, Step 2, using the following starting materials: [2′-ethylaminomethyl-6-methoxy-4′-(1-methyl-1H-pyrazol-4-yl)-biphenyl-3-yl]-acetic acid ethyl ester and benzyl isocyanate.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0c4c33072352495c99d1b60f12116c09
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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